{"id":62319,"date":"2026-03-27T00:35:52","date_gmt":"2026-03-27T00:35:52","guid":{"rendered":"https:\/\/iarc.spherical.horse\/news-events\/iarc-monographs-evaluation-of-the-carcinogenicity-of-trischloropropyl-phosphate-butyraldehyde-and-cumyl-hydroperoxide\/"},"modified":"2026-05-20T07:31:55","modified_gmt":"2026-05-20T07:31:55","slug":"iarc-monographs-evaluation-of-the-carcinogenicity-of-trischloropropyl-phosphate-butyraldehyde-and-cumyl-hydroperoxide","status":"publish","type":"news-events","link":"https:\/\/iarc.spherical.horse\/fr\/news-events\/iarc-monographs-evaluation-of-the-carcinogenicity-of-trischloropropyl-phosphate-butyraldehyde-and-cumyl-hydroperoxide\/","title":{"rendered":"<em>IARC Monographs<\/em> evaluation of the carcinogenicity of tris(chloropropyl) phosphate, butyraldehyde, and cumyl hydroperoxide"},"content":{"rendered":"<p>27The results of the recent <em>IARC Monographs<\/em> evaluation of three chemicals \u2013 tris(chloropropyl) phosphate (TCPP), butyraldehyde, and cumyl hydroperoxide \u2013 have now been published in <em>The Lancet Oncology<\/em>. The summary article presents the conclusions of <em>IARC Monographs <\/em>Meeting 141.<\/p>\r\n<p>All three chemicals were accorded high priority by the <a href=\"https:\/\/monographs.iarc.who.int\/wp-content\/uploads\/2024\/11\/AGP_Report_2025-2029.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Advisory Group to Recommend Priorities<\/a> for the <em>IARC Monographs<\/em> during 2025\u20132029, and each was evaluated by the <em>IARC Monographs<\/em> programme for the first time.<\/p>\r\n<p>All three are chemicals with a high production volume and wide-ranging uses in industry. Butyraldehyde and cumyl hydroperoxide are used in the production of chemical intermediates, and TCPP is a flame retardant in polyurethane foams.<\/p>\r\n<p>TCPP was classified as <em>probably carcinogenic to humans <\/em>(Group 2A) on the basis of the combination of <em>sufficient<\/em> evidence for cancer in experimental animals and <em>strong<\/em> mechanistic evidence in human primary cells. The Working Group classified butyraldehyde as <em>possibly carcinogenic to humans<\/em> (Group 2B) in two ways: (i) <em>sufficient<\/em> evidence for cancer in experimental animals; and (ii) <em>strong<\/em> mechanistic evidence in experimental systems. Cumyl hydroperoxide was classified in Group 2B on the basis of <em>strong<\/em> mechanistic evidence in human primary cells and experimental systems. For all three chemicals, the evidence regarding cancer in humans was <em>inadequate<\/em>.<\/p>\r\n<p>The full scientific assessment will be published as Volume 141 of the <em>IARC Monographs<\/em>.<\/p>\r\n<p>Lachenmeier DW, Arrandale VH, DeMarini DM, Ruksha T, Abdallah MA, Bettini G, et al.<br \/>\r\nCarcinogenicity of tris(chloropropyl) phosphate, butyraldehyde, and cumyl hydroperoxide<br \/>\r\n<em>Lancet Oncol<\/em>. Published online 27 March 2026;<br \/>\r\nhttps:\/\/doi.org\/10.1016\/S1470-2045(26)00168-3<\/p>\r\n<p><a href=\"https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(26)00168-3\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Read the article<\/a>\u00a0<\/p>\r\n<p><a href=\"\/wp-content\/uploads\/2026\/03\/QA-Mono-Vol141.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Read the Q&amp;A<\/a><\/p>\r\n<p><a href=\"\/wp-content\/uploads\/2026\/03\/infographic_mono_vol_141.jpg\" target=\"_blank\" rel=\"noopener noreferrer\">View the infographic<\/a><\/p>","protected":false},"featured_media":42920,"template":"","class_list":["post-62319","news-events","type-news-events","status-publish","has-post-thumbnail","hentry","research-topic_taxonomy-cancer-hazard-identification-fr","risk-factor_taxonomy-dietary-exposures-fr","risk-factor_taxonomy-environmental-exposures-fr","risk-factor_taxonomy-occupational-exposures-fr"],"acf":[],"_links":{"self":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/news-events\/62319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/news-events"}],"about":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/types\/news-events"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/media\/42920"}],"wp:attachment":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/media?parent=62319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}