{"id":58961,"date":"2025-03-21T00:29:25","date_gmt":"2025-03-21T00:29:25","guid":{"rendered":"https:\/\/iarc.spherical.horse\/news-events\/iarc-monographs-evaluation-of-the-carcinogenicity-of-automotive-gasoline-and-some-oxygenated-gasoline-additives\/"},"modified":"2026-07-16T09:41:37","modified_gmt":"2026-07-16T09:41:37","slug":"iarc-monographs-evaluation-of-the-carcinogenicity-of-automotive-gasoline-and-some-oxygenated-gasoline-additives","status":"publish","type":"news-events","link":"https:\/\/iarc.spherical.horse\/fr\/news-events\/iarc-monographs-evaluation-of-the-carcinogenicity-of-automotive-gasoline-and-some-oxygenated-gasoline-additives\/","title":{"rendered":"<em>IARC Monographs<\/em> evaluation of the carcinogenicity of automotive gasoline and some oxygenated gasoline additives"},"content":{"rendered":"<p>The International Agency for Research on Cancer (IARC) has evaluated the carcinogenicity of automotive gasoline and some oxygenated gasoline additives. The outcome of the assessment has been published in a summary article in <em>The Lancet Oncology<\/em>.<\/p>\r\n<p>Automotive gasoline is a commercial product and a complex mixture primarily used as a fuel in internal combustion engines. Methyl <em>tert<\/em>-butyl ether (MTBE), ethyl <em>tert<\/em>-butyl ether (ETBE), <em>tert<\/em>-butyl alcohol (TBA), diisopropyl ether (DIPE), and <em>tert<\/em>-amyl methyl ether (TAME) are volatile compounds used as oxygenated additives in gasoline to increase combustion efficiency, and more commonly since the elimination of lead.<\/p>\r\n<p>The Working Group evaluated automotive gasoline as <em>carcinogenic to humans<\/em> (Group 1) on the basis of <em>sufficient<\/em> evidence for cancer in humans and the combination of <em>sufficient<\/em> evidence for cancer in experimental animals and <em>strong<\/em> mechanistic evidence in exposed humans. Automotive gasoline causes cancer of the urinary bladder and acute myeloid leukaemia in adults. The evidence was <em>limited<\/em> for a causal association between automotive gasoline and acute lymphoblastic leukaemia in children, and non-Hodgkin lymphoma (including chronic lymphocytic leukaemia), multiple myeloma, myelodysplastic syndromes, and cancers of the stomach and kidney in adults.<\/p>\r\n<p>MTBE and ETBE were both classified as <em>possibly carcinogenic to humans<\/em> (Group 2B) on the basis of <em>sufficient<\/em> evidence for cancer in experimental animals. TBA, DIPE, and TAME were each evaluated as <em>not classifiable as to its carcinogenicity <\/em><em>to humans<\/em> (Group 3). For all the oxygenated gasoline additives, the evidence regarding cancer in humans was <em>inadequate<\/em>.<\/p>\r\n<p>The full scientific assessment will be published as Volume 138 of the <em>IARC Monographs.<\/em><\/p>\r\n<p>Turner MC, Godderis L, Gu\u00e9nel P, Hopf N, Quintanilla-Vega B, Soares-Lima SC, et al.<br \/>\r\nCarcinogenicity of automotive gasoline and some oxygenated gasoline additives<br \/>\r\n<em>Lancet Oncol<\/em>. Published online 21 March 2025;<br \/>\r\nhttps:\/\/doi.org\/10.1016\/S1470-2045(25)00165-2<\/a><\/p>\r\n<p><a href=\"https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(25)00165-2\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Read the article<\/a><\/p>\r\n<p><a href=\"\/wp-content\/uploads\/2025\/03\/QA-Mono-Vol138.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Read the Q&amp;A<\/a><\/p>\r\n<p><a href=\"\/wp-content\/uploads\/2025\/03\/infographic_mono_vol_138.jpg\" target=\"_blank\" rel=\"noopener noreferrer\">View the infographic<\/a><\/p>\r\n<p><a href=\"\/video\/iarc-monographs-evaluation-of-the-carcinogenicity-of-automotive-gasoline-and-some-oxygenated-gasoline-additives\/\">Watch the videos<\/a><\/p>","protected":false},"featured_media":42920,"template":"","class_list":["post-58961","news-events","type-news-events","status-publish","has-post-thumbnail","hentry","cancer-site_taxonomy-bladder-cancer-fr","cancer-site_taxonomy-childhood-cancer-fr","cancer-site_taxonomy-kidney-cancer-fr","cancer-site_taxonomy-leukaemia-fr","cancer-site_taxonomy-multiple-myeloma-fr","cancer-site_taxonomy-non-hodgkin-lymphoma-fr","cancer-site_taxonomy-stomach-cancer-fr","research-topic_taxonomy-cancer-hazard-identification-fr","risk-factor_taxonomy-environmental-exposures-fr","risk-factor_taxonomy-occupational-exposures-fr"],"acf":[],"_links":{"self":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/news-events\/58961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/news-events"}],"about":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/types\/news-events"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/media\/42920"}],"wp:attachment":[{"href":"https:\/\/iarc.spherical.horse\/fr\/wp-json\/wp\/v2\/media?parent=58961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}